OBJECTIVE
1.To
determine the friability of tablets to withstand with damaged.
INTRODUCTION
Tablet Friability is the evaluation the ability of
tablets to withstand abrasion, packaging, handling and shipping. It can also be
defined as the phenomenon whereby tablet surfaces are damaged and /or show
evidence of lamination or breakage when subjected to mechanical shock or
attrition.Tablets must be able to
withstand mechanical stresses during their manufacturing, distribution and
handling by the end-user. Both friability and hardness measure the mechanical
integrity of tablets.
Tablets are constantly subjected to mechanical
shocks and aberration to manufacturing, packing and transportation process.
Such stress can lead to capping, aberration areve breakage of tablets. It is
therefore important that the tablet is formulated to withstand such stress. In
order to monitor the resistance of tablets to such stress and to decide on
their suitability for further processing such as coating, tablets are routinely
subjected to friability test.
MATERIALS
AND APPARATUS
Materials : 10 tablets
Apparatus : Friability tester machine, weighing boat
PROCEDURES
1.Select 10 tablets and weighed.
2.All the tablets are put into the drum of the
tablet aberration and friability. The rate of rotation is set to 100 rpm time
to 10 minutes and start the operation.
3.At the end of the operation, remove all the
tablets and ensure freedom from dust or powder. The tablets are reweighed and
determine the percentage loss of weigh.
Tablets used in this
experiment are Paralgin tablet 500mg.
|
Condition
|
Total weight of 10 tablets(g)
|
|
Before
undergoing friability test
|
6.7692
|
|
After
undergoing friability test
|
6.7674
|
The percentage loss of weight = [(0.0018) /
(6.7692)] x 100%
0.027%
DISCUSSION
Friability is the tendency for a tablet to chip, crumble or
break following compression. This tendency is normally confined to uncoated
tablets and surfaces during handling or subsequent storage.It can be caused by
a number of factors including poor tablet design (too sharp edges), low moisture
content and insufficient binder.For obvious reasons, tablets need to be hard
enough such that they do not break up in the bottle but friable enough that
they disintegrate in the gastrointestinal tract.
Friability is defined
as the percentage of weight loss by tablets due to mechanical action during the
test. Tablets are weighing before and after testing and friability are
expressed as a percentage loss on pre test tablet weight. Friability refers the
ability of the compressed tablets to avoid fracture and breaking during
transport. Friability is closely related to tablet hardness .It is designed to withstand aberration in
packing, handling and shipping. Friability is usually measured by the use of
Roche fibrilatoror tumbler test.
A number of tablets are weighed and placed in the
apparatus where they are exposed to rolling and repeated shocks as they fall 6
inches in each turn within the apparatus. After that the tablets are weighed
and the weight compared with initial weight. The loss due to abrasion is
measure of tablet friability. The value is expressed in percentage. Minimum
weight loss of the tablet should not be more 1%. There should not be any broken
tablet.The weight loss of Paralgin tablet is less than 1% which mean that the
tablets are strong and hard enough to withstand from breaking easily during the
packing, handling and also shipping.
Normally, when capping
occurs, friability values are not calculated. A thick tablet may have less
tendency to cap whereas thin tablets of large diameter often show extensive
capping, thus indicating that tablets with greater thickness have reduced
internal stress.
Effervescent tablets
and chewable tablets may have different specifications as far as friability is
concerned. In the case of hygroscopic tablets, an appropriate
humidity-controlled environment is required for testing
CONCLUSION
1.The weight loss of Paralgin tablet is 0.027% which
mean that the tablets are strong and hard enough to withstand from breaking
easily during the packing, handling and also shipping.
REFERENCES
1.http://www.anabiotec.com/testing/detail/hardness-friability-disintegration
2.http://www.slideshare.net/donjacob81/tablet-friabilityharness-and-dissolution-testing
3.http://www.copleyscientific.com/home/pharmaceutical-testing/friability-testing/introduction-to-friability-testing
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